Mutational activation of ras genes is absent in pediatric osteosarcoma

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Mutational activation of ras genes is absent in pediatric osteosarcoma.

Activation of ras oncogenes is found in human cancers; overall it is observed in 15% of all neoplasms. The purpose of this study was to assess the extent of involvement of ras oncogenes in osteosarcoma. Tumor samples from a series of 49 pediatric patients diagnosed with osteosarcoma and treated at our institution were evaluated. Paraffin-embedded tumor samples from diagnostic biopsies, from tum...

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ژورنال

عنوان ژورنال: Cancer Genetics and Cytogenetics

سال: 1995

ISSN: 0165-4608

DOI: 10.1016/0165-4608(94)00115-r